人和猩猩DNA序列的全基因组比较
送给大家吧！这是文件是WORD格式,资源大小为242K　让大家对这方面的知识有最新的了解,对大家对科技前沿的把握上有着很大的好处,希望大家用的愉快.A total of 8,859 DNA sequences encompassing ～1.9millionbasepairsofthechimpanzeegenomeweresequenced
andcomparedtocorrespondinghumanDNAsequences.Althoughtheaveragesequencedifferenceislow(1.24%),
theextentofchangesismarkedlydifferentamongsitesandtypesofsubstitutions.Whereas ～15%ofallCpGsites
haveexperiencedchangesbetweenhumansandchimpanzees,owingtoa23-foldexcessoftransitionsanda7-fold
excessoftransversions,substitutionsatothersitesvaryinfrequency,between0.1%and0.5%.Ifthenucleotide
diversityinthecommonancestralspeciesofhumansandchimpanzeesisassumedtohavebeenaboutfourfold
higherthanincontemporaryhumans,allpossiblecomparisonsbetweenautosomesandXandYchromosomes
resultinestimatesoftheratiobetweenmaleandfemalemutationratesof ～3.Thus,therelativetimespentinthe
maleandfemalegermlinesmaybeamajordeterminantoftheoverallaccumulationofnucleotidesubstitutions.
However,sincetheextentofdivergencedifferssignificantlyamongautosomes,additionalunknownfactorsmust
alsoinfluencetheaccumulationofsubstitutionsinthehumangenome.