[计算生物学] - Introduction to Computational Biology
This textbook is intended for students enrolled in

courses in computational biology or bioinformatics as

well as for molecular biologists, mathematicians, and

computer scientists.Analysis of molecular sequence

data is the main subject of this introduction to

computational biology. There are two closely connected

aspects to biological sequences: (i) their relative

position in the space of all other sequences, and (ii)

their movement through this sequence space in

evolutionary time. Accordingly, the first part of the

book deals with classical methods of sequence

analysis: pairwise alignment, exact string matching,

multiple alignment, and hidden Markov models. In the

second part evolutionary time takes center stage and

phylogenetic reconstruction, the analysis of sequence

variation, and the dynamics of genes in populations

are explained in detail. In addition, the book

contains a computer program with a graphical user

interface that allows the reader to experiment with a

number of key concepts developed by the authors